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| Catalog Code: | NB110-55563 |
| Product Name: | a-1 Catenin Antibody |
| Product Description: | Rabbit Monoclonal anti-a-1 Catenin (EP1793Y) |
| Clone: | EP1793Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human á-1 catenin was used as an immunogen. |
| Cross Reactivity: | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:50,000IHC: 1:100 - 250ICC: 1:100 - 250FC: 1:50IP: 1:50 |
| Background: | Cadherin and catenin compose cell adhesion complex and are indispensable for tight cell-cell adhesion. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis (1). At least three proteins (alpha, beta, and gamma catenin) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex. Data, with the reported structure of other catenin genes, suggest that vinculin and alpha-catenin generate a superfamily of proteins mediating membrane-cytoskeletal associations (2). Presenilin-1 (PS1) overexpression in human kidney cells enhances cell-cell adhesion and data show that PS1 incorporates into the cadherin/catenin adhesion system and regulates cell-cell adhesion. PS1 concentrates at intercellular contacts in epithelial tissue; in brain, it forms complexes with both E- and N-cadherin and concentrates at synaptic adhesions (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CAP 102 antibody, anti-CAP102 antibody, anti-CTNNA 1 antibody, anti-CTNNA1 antibody, anti-Cadherin associated protein 102kDa antibody, anti-Cadherin associated protein antibody, anti-Catenin (cadherin associated protein) alpha 1 102kDa antibody, anti-Catenin alpha 1 antibody, anti-FLJ36832 antibody, anti-NY REN 13 antigen antibody, anti-alpha E catenin antibody, anti-alpha catenin antibody, anti-alphaE catenin antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Oda T, et al. Biochem Biophys 193(3):897-904, 1993 2. Rimm DL, et al. Biochem Biophys 203(3):1691-9, 1994 3. Georgakopoulos A, et al. Mol Cell 4(6):893-902, 1999. |
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