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| Catalog Code: | NB110-55559 |
| Product Name: | Btk (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Btk (C-term) (Y440) |
| Clone: | Y440 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human Btk was used as immunogen. |
| Cross Reactivity: | Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1: 500IP: 1: 20 |
| Background: | Btk (Bruton tyrosine kinase also known as BPK or ATK) is a member of the TEC family of non-receptor protein tyrosine kinase which includes Bmx, Itk and TEC. Btk is composed of a pleckstrin domain, an SH3 and SH2 domain, a catalytic kinase domain and a TEC homology domain (1). BTK plays a crucial role in B cell activation and development (2). Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a ligand-independent manner (3) Mutations in the Btk gene have been linked to severe developmental blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia (XLA). Patients with this disease are unusually prone to bacterial infection but not to viral infection. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-B cell progenitor kinase antibody, anti-BPK antibody, anti-Bruton agammaglobulinemia tyrosine kinase antibody, anti-Bruton tyrosine kinase antibody, anti-Bruton's Tyrosine Kinase antibody, anti-IMD 1 antibody, anti-IMD1 antibody, anti-MGC126261 antibody, anti-MGC126262 antibody, anti-OTTHUMP00000063593 antibody, anti-PSCTK 1 antibody, anti-PSCTK1 antibody, anti-Tyrosine protein kinase BTK antibody, anti-XLA antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Tsukada, S., Saffaran, D., Rawlings, D. & Witte, O. (1993) Cell 72, 279-290 2. Rawlings, D. J. & Witte, O. N. (1995) Semin. Immunol. 7, 237-246 3. 3. Vassilev, A., Z. Ozer, C. Navara, S. Mahajan, and F. M. Uckun. 1999. J. Biol. Chem. 274:1646-1656 4.Yun Qiu, Dan Robinson, Tom G. Pretlow, and Hsing-Jien Kung, Cell Biology, Vol. 95, Issue 7, 3644-3649, March 31, 1998 |
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