| CatalogCode: | NB110-55558 |
| ProductName: | BLNK Antibody |
| Product Description: | Rabbit Monoclonal anti-BLNK (Y491) |
| Clone: | Y491 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-term of human BLNK was used as immunogen. |
| CrossReactivity: | Human and Mouse. Does not react in Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1: 500IHC: 1:50IP: 1: 20 |
| Background: | B-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecular complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3). In addition, BLNK binds Btk and is required for activation of the transcription factor NF-ęB. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.5% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | anti-B cell adapter containing SH2 domain protein antibody, anti-B cell adapter containing Src homology 2 domain protein antibody, anti-B cell linker antibody, anti-B cell linker protein antibody, anti-BASH antibody, anti-BLNK s antibody, anti-Bca antibody, anti-Cytoplasmic adapter protein antibody, anti-Ly 57 antibody, anti-Ly57 antibody, anti-Lymphocyte antigen 57 antibody, anti-Lyw 57 antibody, anti-Lyw57 antibody, anti-MGC111051 antibody, anti-SLP 65 antibody, anti-SLP65 antibody, anti-Src homology 2 domain containing leukocyte protein of 65 kDa antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Fu C., Turck,C., Kurosaki,T. and Chan,A. (1998) Immunity, 9, 93-103 2. Jumaa H., Mitterer,M., Reth,M. and Nielsen,P.J. (2001) Eur. J. Immunol., 31, 2164-2169. 3. Hashimoto S. et al. (1999). Blood, 94, 2357-2364 4. Christopher W. Chiu, Mark Dalton, Masamichi Ishiai,Tomohiro Kurosaki,and Andrew C. Chan; EMBO J. 2002 December 2; 21(23): 6461-6472. |
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