| CatalogCode: | NB110-55553 |
| ProductName: | Bcl-6 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Bcl-6 (C-term) (EP529Y) |
| Clone: | EP529Y |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide (Human) - corresponding to residues in the C terminal region of Bcl6. |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human Bcl-6 was used as immunogen. |
| CrossReactivity: | Human. Does not react with Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:500-2,000IHC: 1: 50-100ICC: 1:100-250IP: 1:50 |
| Background: | Bcl-6 (also known as LAZ3) is a member of the POZ/zinc finger (POK) family that contains an N-terminal POZ domain and 6 C-terminal zinc finger motifs (1). Bcl-6 is a transcriptional regulator that plays an important role in lymphocyte, myocyte, male germ cells, and keratinocyte survival and or differentiation (2-3). Bcl-6 has also been found to repress a number of genes involved in B cell activation and terminal differentiation, inflammation and cell cycle regulation (4). Chromosomal aberration in Bcl-6 may be a cause of B-cell non -Hodgkin lymphoma and B-cell leukemia (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-B cell CLL/lymphoma 6 antibody, anti-B cell lymphoma 6 protein antibody, anti-BCL 5 antibody, anti-BCL5 antibody, anti-BCL6A antibody, anti-Bcl 6 antibody, anti-LAZ 3 antibody, anti-LAZ 3 protein antibody, anti-LAZ3 antibody, anti-Lymphoma associated zinc finger gene on chromosome 3 antibody, anti-ZBTB 27 antibody, anti-ZBTB27 antibody, anti-ZNF 51 antibody, anti-ZNF51 antibody, anti-Zinc finger and BTB domain containing protein 27 antibody, anti-Zinc finger protein 51 antibody, anti-cys his2 zinc finger transcription factor antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Kerckaert, J.-P., Deweindt, C., Tilly, H., Quief, S., Lecocq, G., and Bastard, C. (1993) Nat. Genet. 5, 66-70 2. Dent, A. L., Shaffer, A. L., Yu, X., Allman, D., and Staudt, L. M. (1997) Science 276, 589-592 3. Kumagai, T., Miki, T., Kikuchi, M., Fukuda, T., Miyasaka, N., Kamiyama, R., and Hirosawa, S. (1999) Oncogene 18, 467-475 4. Shaeffer, A. L., Yu, X., He, Y., Boldrick, J., Chan, E. P., and Staudt, L. M. (2000) Immunity 13, 199-212 5. Baron, B. W.; Nucifora, G.; McCabe, N.; Espinosa, R., III; Le Beau, M. M.; McKeithan, T. W. : Proc. Nat. Acad. Sci. 90: 5262-5266, 1993. |
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