| CatalogCode: | | NB110-55550 |
| ProductName: | | Bcl-10 (C term) Antibody |
| Product Description: | | Rabbit Monoclonal anti-Bcl-10 (C term) (EP606Y) |
| Clone: | | EP606Y |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues in the C-term of human Bcl-10 was used as immunogen. |
| CrossReactivity: | | Human. Does not react with Mouse or Rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:1,000-5,000IHC: 1:100-250ICC: 1:100-250IP: 1:50 |
| Background: | | Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptor-mediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, IP, WB, ICC |
| SpeciesSummary: | | Hu, Mu(-), Rt(-) |
| ALTnames: | | anti-B cell CLL/lymphoma 10 antibody, Bcl 10 antibody, CARD containing apoptotic signaling protein antibody, CARD containing molecule enhancing NF kB antibody, CARD containing molecule enhancing NF kappa B antibody, CARD containing molecule enhancing NFkB antibody, CARD containing proapoptotic protein antibody, CARD like apoptotic protein antibody, CARMEN antibody, CED 3/ICH 1 prodomain homologous E10 like regulator antibody, CED3/ICH1 prodomain homologous E10 like regulator antibody, CIPER antibody, CLAP antibody, Caspase recruiting domain containing protein antibody, Cellular E10 antibody, Cellular homolog of vCARMEN antibody, Mammalian CARD containing adapter molecule E10 antibody, c E10 antibody, cCARMEN antibody, cE 10 antibody, cE10 antibody, hCLAP antibody, mE 10 antibody, mE10 antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Wotherspoon, A. C.; Pan, L. X.; Diss, T. C.; Isaacson, P. G. : Cancer Genet. Cytogenet. 58: 35-38, 1992 2. Zhang, Q. et al. 1999.Nat. Genet. 22:63-68 3. Ruland, J. et al. 2001. Cell. 104:33-42. 4. Ruefli-Brasse et al. Science. 302:1581-1584 |
| more information: | | company product webpage |
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