| CatalogCode: | NB110-55490 |
| ProductName: | BAG1 Antibody |
| Product Description: | Rabbit Monoclonal anti-BAG1 (Y166) |
| Clone: | Y166 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues following the repeat 7 of human Bag-1 was used as immunogen. The antibody should recognize all three isoforms of Bag-1 (Bag-1L, Bag-1M and Bag-1S). |
| CrossReactivity: | Human, and Rat. Does not react with Mouse. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:500IHC: 1:100-250ICC: 1:100-250IP: 1:80 |
| Background: | Members of the Bcl-2 family of proteins play varied stimulatory or inhibitory roles in the regulation of programmed cell death, or apoptosis. One member of this family, Bcl2-Interacting Protein-1 (BAG-1), functions in conjunction with Bcl-2 to inhibit apoptosis (1,2). BAG-1 is a heat shock 70 kDa (Hsp70)-binding protein (3) that is localized to either the cytosol, nucleus or both. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt |
| ALTnames: | anti-Bag 1 antibody, anti-BAG family molecular chaperone regulator 1 antibody, anti-BCL 2 Associated Athanogene 1 antibody, anti-BCL 2 associated athanogene antibody, anti-BCL 2 binding athanogene 1 antibody, anti-BCL2 associated athanogene 1 antibody, anti-BCL2 associated athanogene antibody, anti-Glucocorticoid receptor-associated protein RAP46 antibody, anti-HAP1 antibody, anti-Haptoglobin antibody, anti-RAP 46 antibody, anti-RAP46 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Takayama, S. et al. Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Genomics 35: 494-498 (1996). 2. Matsuzawa, S. et al. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J. 17: 2736-47 (1998). 3. Takayama, S. et al. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 274: 781-6 (1999). |
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