| CatalogCode: | NB110-55488 |
| ProductName: | B7-2/CD86 Antibody |
| Product Description: | Rabbit Monoclonal anti-B7-2/CD86 (EP1158Y) |
| Clone: | EP1158Y |
| Clonality: | Monoclonal |
| Immunogen: | synthetic peptide corresponding to residues near the N-terminus of human B7-2 was used as an immunogen |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human B7-2 was used as an immunogen. |
| CrossReactivity: | Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:5000IHC: 1:100 - 250ICC: 1:100 - 250FC: 1:10IP: 1:50 |
| Background: | B7-2 (CD86) is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain (1). Engagement of CD28 with B7-1 and B7-2 ligands on antigen-presenting cells (APCs) provides a stimulatory signal for T-cell activation, whereas subsequent engagement of CTLA-4 with these same ligands results in attenuation of the response. Given their central function in immune modulation, CTLA-4- and CD28-associated signaling pathways are primary therapeutic targets for preventing autoimmune disease, graft versus host disease, graft rejection and promoting tumor immunity (2). It has also been shown that on B cells and macrophages, heat shock proteins GroES and GroEL both stimulated the expression of B7-2 (3) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-FUN1 antibody, anti-Activation B7 2 antigen antibody, anti-Activation B72 antigen antibody, anti-B lymphocyte activation antigen B7 2 antibody, anti-B lymphocyte activation antigen B72 antibody, anti-B7 2 antibody, anti-B7 2 antigen antibody, anti-B70 antibody, anti-BU63 antibody, anti-CD 86 antibody, anti-CD28 antigen ligand 2 antibody, anti-CD28LG2 antibody, anti-CD86 antigen antibody, anti-CD86 molecule antibody, anti-CTLA 4 counter receptor B7 2 antibody, anti-CTLA 4 counter receptor B7.2 antibody, anti-CTLA4 counter receptor B72 antibody, anti-FUN 1 antibody, anti-LAB72 antibody, anti-MGC34413 antibody, anti-T lymphocyte activation antigen CD86 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Jeannin P, et al. Immunity 13(3):303-12, 2000. 2. Schwartz JC, et al. Nature 410(6828):604-8, 2001. 3. Galdiero M, et al. Int. J Immunopathol Pharmacol 18(4):637-44, 2005. |
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