| CatalogCode: | NB110-55472 |
| ProductName: | ATF2 Antibody |
| Product Description: | Rabbit Monoclonal anti-ATF2 (E243) |
| Clone: | E243 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in C-terminus of human ATF2 was used as immunogen. The antibody does not cross-react with other ATF family members. |
| CrossReactivity: | Human and Mouse. Does not react with Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:10,000IHC: 1:250-500ICC: 1:250-500IP: 1:60 |
| Background: | ATF-2 (activating transcription factor-2, CRE-BP1) is a transcription factor that binds the cAMP response element (CRE) and AP-1 response element and is abundantly expressed in the brain. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2 (2). SAPK and p38 MAPK can activate, in response to cellular stress, ATF-2 by phosphorylating this protein at Thr69 and Thr71. Mutations of these sites result in the loss of stress-induced transcription by ATF-2 (2-4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 00.5% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | anti-Activating Transcription Factor 2 antibody, anti-cAMP Response Element Binding Protein 2 antibody, anti-CRE BP1 antibody, anti-CREB 2 antibody, anti-CREB2 antibody, anti-CREBP1 antibody, anti-HB 16 antibody, anti-HB16 antibody, anti-MGC111558 antibody, anti-mXBP antibody, anti-TREB 7 antibody, anti-TREB7 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Maekawa, T., et al. Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J. 8: 2023-8 (1989). 2. Gupta, S., et al. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267: 389-393 (1995). 3. van Dam, H., et al. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14: 1798-1811 (1995). 4. Livingstone, C., et al. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14: 1785-1797 (1995). |
order or
more information: | company product webpage |
| request information: |
|
|