| CatalogCode: | NB110-55466 |
| ProductName: | Apolipoprotein E (apo E) Antibody |
| Product Description: | Rabbit Monoclonal anti-Apolipoprotein E (apo E) (EP1374Y) |
| Clone: | EP1374Y |
| Clonality: | Monoclonal |
| Immunogen: | A synthetic peptide corresponding to residues near the C-term of human apolipoprotein E. |
| Specificity: | A synthetic peptide corresponding to residues near the C-term of human apolipoprotein E was used as an immunogen. |
| CrossReactivity: | Human, Mouse. Does not react with Rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | This antibody works for IHC, IP, WB, and ICC. |
| Localization: | Secreted |
| Control: | Human serum; human normal liver tissue; HepG2 cells. |
| Background: | The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl, 40% Glycerol, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BS |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | anti-Acetaldehyde dehydrogenase 1 antibody; anti-AHD2 antibody; anti-ALDC antibody; anti-Aldehyde dehydrogenase 1 family member A1 antibody; anti-Aldehyde dehydrogenase 1 soluble antibody; anti-Aldehyde dehydrogenase 1A1 antibody; anti-Aldehyde Dehydrogenase antibody; anti-Aldehyde dehydrogenase cytosolic antibody; anti-Aldehyde dehydrogenase family 1 member A1 antibody; anti-Aldehyde dehydrogenase liver cytosolic antibody; anti-ALDH 1 antibody; anti-ALDH 1A1 antibody; anti-ALDH class 1 antibody; anti-ALDH-E1 antibody; anti-ALDH1 A1 antibody; anti-ALDH1 antibody; anti-ALDH11 antibody; anti-ALHDII antibody; anti-MGC2318 antibody; anti-PUMB1 antibody; anti-RALDH 1 antibody; anti-RalDH1 antibody; anti-Retinal dehydrogenase 1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Zaioua M et al, Journal of Lipid Research, 41:1087-1095, 2000 2. Mahley RW and SC Rall, Jr. 7th ed. McGraw-Hill, New York. 1995. 3. Olarte L et al, Arch Neurol. 63(11):1586-90, 2006 |
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