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| Catalog Code: | NB110-55464 |
| Product Name: | APC Antibody |
| Product Description: | Rabbit Monoclonal anti-APC (EP701Y) |
| Clone: | EP701Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues near the N-terminus of human APC. The amino acid sequence is not available. |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human APC was used as immunogen. This antibody is predicted to detect isoform 2 based on sequence analysis. |
| Cross Reactivity: | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:500-1,000IHC: 1:50-100ICC: 50-100IP: 1:50 |
| Background: | Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling (1). APC regulates â-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration (2-3). Mutations cause the production of an APC protein that is abnormally short and nonfunctional. Defects in APC are a cause of familial aenomatous polyposis (FAP), Turcot syndrome, medulloblastoma (MDB), and other cancers. (4-6) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry , immunoprecipitation , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-APC antibody, anti-Adenomatous Polyposis Coli antibody, anti-APC antibody, anti-Adenomatous Polyposis Coli antibody, anti-DP2 antibody, anti-DP2.5 antibody, anti-DP3 antibody, anti-FAP antibody, anti-FPC antibody, anti-GS antibody, anti-Protein APC antibody, anti-DP2 antibody, anti-DP2.5 antibody, anti-DP3 antibody, anti-FAP antibody, anti-FPC antibody, anti-GS antibody, anti-Protein APC antibod antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Senda T, Shimomura A, Iizuka-Kogo A. Anat Sci Int. 2005 Sep;80(3):121-31. 2. Narayan S, Roy D. Mol Cancer. 2003 Dec 12;2:41. 3. van Es JH, Giles RH, Clevers HC. Exp Cell Res. 2001 Mar 10;264(1):126-34. 4. Jarvinen HJ, Peltomaki P. Eur J Gastroenterol Hepatol. 2004 Jan;16(1):5-8. 5. Jaiswal AS, Balusu R, Narayan S. Front Biosci. 2005 May 1;10:1118-34. 6. Cohen MM Jr. Am J Med Genet A. 2003 Nov 1;122(4):303-14. |
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