| CatalogCode: | | NB110-55462 |
| ProductName: | | Androgen Receptor Antibody |
| Product Description: | | Rabbit Monoclonal anti-Androgen Receptor (EP670Y) |
| Clone: | | EP670Y |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues on the C-terminus of human Androgen Receptor was used as an immunogen. |
| CrossReactivity: | | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:10,000FC: 1:60 |
| Background: | | Androgen receptor (AR) is a member of the steroid receptor superfamily that may require coactivators for proper or maximal transactivation. (1). The androgen receptor (AR) is essential for the growth of prostate cancer cells. It has been reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Data suggest that growth factors and their downstream tyrosine kinases, which are elevated during hormone-ablation therapy, can induce tyrosine phosphorylation of AR and such modification may be important for prostate tumor growth under androgen-depleted conditions (2). Cellular signaling occurs following androgen binding to the AR and translocation to the nucleus. This activated complex associates with androgen-responsive elements contained in the DNA sequence of target genes, affecting the transcriptional activity of these genes. Mutations may result in changes in the function or expression of AR protein, or of growth factors and their receptors under the influence of AR coactivators, and AR amplification could lead to activation of the receptor by reduced levels of androgens (3). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | FACS, WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Callewaert L, et al. Biochem Biophys Res Commun 306(1) 46-52, 2003. 2. Qiu Y, et al. Cancer Cell Vol 10:309-319, 2006. 3. Hamdy F, et al. Nature Clinical Practice Urology 2:368-399 2005. |
| more information: | | company product webpage |
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