| CatalogCode: | NB110-55459 |
| ProductName: | AMPK gamma 1 Antibody |
| Product Description: | Rabbit Monoclonal anti-AMPK gamma 1 (Y308) |
| Clone: | Y308 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human AMPK gamma-1 subunit was used as an immunogen |
| CrossReactivity: | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:1,000Flow Cytometry: 1:20IP: 1:50 |
| Background: | The 5'-AMP-activated protein kinase (AMPK), a member of the SNF1 (sucrose non-fermentor) kinase family (1) AMPK is a heterotrimeric protein comprising á (63 kDa), â (38 kDa) and ã (38 kDa) subunits. The alpha subunit is the catalytic subunit, while beta and gamma are non-catalytic subunits, although they have been found to interact with the active subunit in liver. AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (2). AMPK is activated by AMP and can be also regulated by treatment with purified protein phosphatase in vitro (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-PRKAG 1 antibody, anti-PRKAG1 antibody, anti-5 -AMP-activated protein kinase gamma-1 subunit antibody, anti-5' AMP activated protein kinase subunit gamma 1 antibody, anti-AMP activated protein kinase noncatalytic gamma 1 subunit antibody, anti-AMPK gamma 1 chain antibody, anti-AMPKg antibody, anti-PRKAG 1, anti-PRKAG1, anti-5 -AMP-activated protein kinase gamma-1 subunit, anti-5' AMP activated protein kinase subunit gamma 1, anti-AMP activated protein kinase noncatalytic gamma 1 subunit, anti-AMPK gamma 1, anti-AMPK gamma 1 chain, anti-AMPKg, anti-MGC8666, anti-PRKAG 1, anti-PRKAG1, anti-Protein kinase AMP-activated gamma 1 non-catalytic subunit, anti-MGC8666 antibody, anti-PRKAG 1 antibody, anti-PRKAG1 antibody, anti-Protein kinase AMP-activated gamma 1 non-catalytic subunit antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Mitchelhill, K. I., Stapleton, D., Gao, G., House, C., Michell, B., Katsis, F., Witters, L. A., and Kemp, B. E. (1994) J. Biol. Chem. 269, 2361-2364 2. Carling, D., Clarke, P. R., Zammit, V. A., and Hardie, D. G. (1989) Eur. J. Biochem. 186, 129-136 3. Carling, D., Zammit, V. A,, and Hardie, D. G. (1987) FEES Lett. 223,217-222 |
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