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| Catalog Code: | NB110-55453 |
| Product Name: | ALK Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho ALK (pY1604) (EP661Y) [Tyr1604] |
| Clone: | EP661Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic phosphor-peptide corresponding to residues surrounding Tyr1604 of human ALK. |
| Specificity: | A synthetic phosphor-peptide corresponding to residues surrounding Tyr1604 of human ALK was used as an immunogen. The antibody only detects ALK phosphorylated on Tyrosine 1604. |
| Cross Reactivity: | Human. Does not react with Mouse and Rat. Not tested in other species. |
| Packaging: | 0.1 ml protein A purified Rabbit ascites. |
| Uses: | WB: 1:5000IHC: 1:100 - 250IP: 1:20 |
| Background: | ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23 (1). In the predicted hybrid protein, the amino terminus of NPM is linked to the catalytic domain of ALK. Immunoblotting with anti-ALK antibody shows that ALK is highly expressed in the neonatal brain (2). Also expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry , immunoprecipitation , Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-ALK tyrosine kinase receptor antibody, anti-ALK tyrosine kinase receptor precursor antibody, anti-Anaplastic lymphoma kinase Ki 1 antibody, anti-Anaplastic lymphoma kinase Ki1 antibody, anti-Anaplastic lymphoma kinase antibody, anti-Anaplastic lymphoma kinase p80 antibody, anti-ALK, anti-ALK tyrosine kinase receptor, anti-ALK tyrosine kinase receptor precursor, anti-Anaplastic lymphoma kinase, anti-Anaplastic lymphoma kinase Ki 1, anti-Anaplastic lymphoma kinase Ki1, anti-Anaplastic lymphoma kinase p80, anti-CD 246, anti-CD246, anti-CD246 antigen, anti-Ki 1, anti-Ki1, anti-TFG/ALK, anti-CD 246 antibody, anti-CD246 antibody, anti-CD246 antigen antibody, anti-Ki 1 antibody, anti-Ki1 antibody, anti-TFG/ALK antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Tyr1604 |
| General References: | 1. Morris SW, et al. Science 263(5151):1281-4, 1994. 2. Iwahara T, et al. Oncogene 14(4):439-49, 1997. 3. Benharroch D, et al. Blood 91(6): 2076-84, 1998. |
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