| CatalogCode: | | NB110-55451 |
| ProductName: | | Aldh1a1 Antibody |
| Product Description: | | Rabbit Monoclonal anti-Aldh1a1 (EP1933Y) |
| Clone: | | EP1933Y |
| Clonality: | | Monoclonal |
| Immunogen: | | Synthetic peptide corresponding to residues near the C-terminus of human Aldh1a1 |
| Specificity: | | A synthetic peptide corresponding to residues near the C-terminus of human Aldh1a1 was used as an immunogen. |
| CrossReactivity: | | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | | This antibody works for IHC, IP, WB, ICC and is unsuitable for Flow Cyt. |
| Localization: | | Cytoplasmic |
| Control: | | HepG2 cell lysate; human liver tissue |
| Background: | | Usual human livers contain two major ALDH isozymes, i.e., cytosolic ALDH1 and mitochondrial ALDH2(1). Human red cell aldehyde dehydrogenase (ALDH) resembles the liver cytosolic isozyme in numerous physicochemical properties. Thus, the erythrocyte enzyme, by virtue of its chemical and structural identity with the liver cytosolic enzyme, may serve as a suitable peripheral enzyme model to understand the cause and mechanism of alcohol abuse-related changes in liver cytosolic ALDH that has been found to be reduced in alcoholics (2). ALDH1A1 is known to catalyze the oxidation of retinaldehyde to retinoic acid. Overexpression of human ALDH1A1 in HEK cells led to a more than 20-fold increase in 3-deoxyglucosone dehydrogenase activity (3). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Tissue culture supernatant |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, IP, WB, ICC |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | anti-Acetaldehyde dehydrogenase 1 antibody; anti-AHD2 antibody anti-ALDC antibody; anti-Aldehyde dehydrogenase 1 family member A1 antibody; anti-Aldehyde dehydrogenase 1 soluble antibody; anti-Aldehyde dehydrogenase 1A1 antibody; anti-Aldehyde Dehydrogenase antibody; anti-Aldehyde dehydrogenase cytosolic antibody; anti-Aldehyde dehydrogenase family 1 member A1 antibody; anti-Aldehyde dehydrogenase liver cytosolic antibody; anti-ALDH 1 antibody; anti-ALDH 1A1 antibody; anti-ALDH class 1 antibody; anti-ALDH-E1 antibody; anti-ALDH1 A1 antibody; anti-ALDH1 antibody anti-ALDH11 antibody; anti-ALHDII antibody; anti-MGC2318 antibody anti-PUMB1 antibody; anti-RALDH 1 antibody; anti-RalDH1 antibody; anti-Retinal dehydrogenase 1 antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Yoshida A, et al. Alcohol 2(1):103-6, 1985 2. Agarwal DP, et al. Enzyme 42(1):47-52, 1989 3. Collard F, et al. Biochimie 89(3):369-73, 2007 |
| more information: | | company product webpage |