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| Catalog Code: | NB110-55442 |
| Product Name: | Adducin alpha Antibody |
| Product Description: | Rabbit Monoclonal anti-Adducin alpha (C-term) (EP734Y) |
| Clone: | EP734Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human Adducin was used as immunogen. |
| Cross Reactivity: | Human, Mouse. Does not react with rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5,000-50,000IHC: 1:250-500ICC: 1:250-500 |
| Background: | Adducin is a membrane skeletal protein that binds to actin filaments (F-actin) and promotes the association of spectrin with F-actin to form a spectrin-actin meshwork beneath plasma membranes (1-2). Adducin is a heterodimeric protein that consists of related subunits; alpha and beta, or alpha and gamma subunits (3). Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinase C (PKC), and protein kinase A (PKA) (4). Phosphorylation of adducing alpha by Rho-kinase at Thr445 and Thr480 enhances the F-actin-binding activity of adducing alpha (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt(-), |
| Alternate Names: | anti-ADD 1 antibody, anti-ADD A antibody, anti-ADD1 antibody, anti-ADD1 protein antibody, anti-ADDA antibody, anti-Adducin 1 (alpha) antibody, anti-Adducin 1 alpha antibody, anti-Alpha adducin antibody, anti-ADD 1, anti-ADD A, anti-ADD1, anti-ADD1 protein, anti-ADDA, anti-Adducin 1 (alpha), anti-Adducin 1 alpha, anti-Erythrocyte adducin alpha subunit, anti-Erythrocyte adducin alpha subunit, anti-Erythrocyte adducin subunit alpha, anti-MGC3339, anti-MGC44427, anti-alpha Adducin, anti-Erythrocyte adducin alpha subunit antibody, anti-Erythrocyte adducin alpha subunit antibody, anti-Erythrocyte adducin subunit alpha antibody, anti-MGC3339 antibody, anti-MGC44427 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Gardner, K.; Bennett, V. : J. Biol. Chem. 261: 1339-1348, 1986. 2. Kuhlman, P.A., C.A. Hughes, V. Bennett, and V.M. Fowler. 1996. J. Biol. Chem. 271: 7986-7991 3. Dong, L., C. Chapline, B. Mousseau, L. Fowler, K. Ramsay, J.L. Stevens, and S. Jaken. 1995. J. Biol. Chem. 270: 25534-25540 4. Palfrey, H. C., Waseem, A. (1985) J. Biol. Chem. 260, 16021-16029 5. Fukata et al. J. Cell Biol., Volume 145, Number 2, April 19, 1999 347-361 |
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