| CatalogCode: | | NB110-55440 |
| ProductName: | | Acetyl CoA Carboxylase 1 (ACC1) Antibody |
| Product Description: | | Rabbit Monoclonal anti-Acetyl CoA Carboxylase 1 (ACC1) (EP687Y) |
| Clone: | | EP687Y |
| Clonality: | | Monoclonal |
| Immunogen: | | Synthetic peptide corresponding to residues in human Acetyl Coenzyme A Carboxylase. |
| Specificity: | | A synthetic peptide corresponding to residues in the human Acetyl-CoA carboxylase 1 was used as an immunogen. |
| CrossReactivity: | | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | | 0.1 ml Rabbit ascites. |
| Background: | | Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Ascites |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | anti-ACAC antibody, anti-ACC alpha antibody, anti-ACC beta antibody, anti-ACC1 antibody, anti-ACC2 antibody, anti-ACCA antibody, anti-ACCB antibody, anti-Acetyl CoA carboxylase 1 antibody, anti-Acetyl CoA carboxylase alpha antibody, anti-ACAC antibody, anti-ACC alpha antibody, anti-ACC beta antibody, anti-ACC1 antibody, anti-ACC2 antibody, anti-ACCA antibody, anti-ACCB antibody, anti-Acetyl CoA carboxylase 1 antibody, anti-Acetyl CoA carboxylase alpha antibody, anti-Acetyl Coenzyme A Carboxylase antibody, anti-Biotin carboxylase antibody, anti-COA1 antibody, anti-COA2 antibody, anti-HFA1 antibody, anti-Biotin carboxylase antibody, anti-COA1 antibody, anti-COA2 antibody, anti-HFA1 antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Jianqiang M, et al. PNAS 100:7515-7520, 2003. 2. Girad J, et al. The FASEB Journal 8:36-42, 1994. 3. Wakil SJ, et al. Annu Reb Biochem 52:537-579. 1983. 4. Abu-Elheiga L, et al. Science 291: 2613-2616. 2001. |
| more information: | | company product webpage |
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