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| Catalog Code: | NB110-55244 |
| Product Name: | Insig1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Insig1 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Concentration: | 1.02 mg/ml |
| Immunogen: | A synthetic peptide representing an internal region of the human protein (between residues 1-100) according to Swiss-Prot# O15503. |
| Specificity: | This antibody is specific for Insig1 but not Insig2. |
| Cross Reactivity: | This antibody reacts with human protein. Other species have not been tested. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis, where a band is seen at ~ 30 kDa, representing the Insig1 protein. |
| Localization: | Membrane |
| Background: | Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | PBS + 30% glycerol |
| Application Summary: | Western Blot 2 ug/ml |
| Species Summary: | Hu |
| Alternate Names: | anti-Insulin-induced gene 1 protein antibody; anti-INSIG-1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| Homology: | 100% with human protein. No other significant species homology. |
| General References: | 1. Engelking, LJ, et al. J. Clin. Invest. 115(9): 2489-2498 (2005) 2. Gong, Y., Cell Metabolism. 3: 15-24 (2006) |
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