| CatalogCode: | NB110-41563 |
| ProductName: | APAF1 Antibody |
| Product Description: | Rabbit Polyclonal anti-APAF1 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide derived from C-terminus of human Apaf-1. |
| CrossReactivity: | Cross reacts with mouse & rat |
| Packaging: | 0.5 ml Whole antisera Rabbit antisera. |
| Uses: | IHC Incubate for 30 minutes at room temperature. |
| Localization: | Cytoplasmic |
| Control: | Testis |
| Background: | Apaf-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (Apaf-2). The resulting Apaf-1/cytochrome c complex associates with the zymogen form of caspase-9 (Apaf-3) in the presence of dATP or ATP, promoting the autocatalytic activation of caspase-9. This antibody will be useful in studies of the activation of caspases through Apaf-1 and also in metastatic melanomas where Apaf-1 is inactivated which leads to defects in the execution of apoptotic cell death. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Whole antisera |
| Host_Name: | Rabbit |
| ListPrice: | 295 |
| AppSummary: | IHC |
| SpeciesSummary: | Mu, Rt |
| ALTnames: | anti-Apoptotic protease activating factor 1 antibody, anti-CED4 antibody, anti-KIAA0413 antibody |
| PackageSize: | 0.5 ml |