| CatalogCode: | NB110-41544 |
| ProductName: | Katanin p80 B1 Antibody |
| Product Description: | Chicken Polyclonal anti-Katanin p80 B1 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant protein corresponding to amino acids 301-511. |
| CrossReactivity: | Cross reacts with Human, Mouse and Rat. Not tested in any other applications. |
| Packaging: | 0.1 mg Immunogen affinity purified Chicken antisera. |
| Background: | Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 340 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-KAT antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1) Karabay,A., Yu,W., Solowska,J.M., Baird,D.H. and Baas,P.W., et al. Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. J Neurosci. 2004 Jun 23;24(25):5778-88. [2) McNally,K.P., Bazirgan,O.A. and McNally,F.J., et al. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. J Cell Sci. 2000 May;113 ( Pt 9):1623-33. 3) Ahmad,F.J., Yu,W., McNally,F.J. and Baas,P.W., et al. An essential role for katanin in severing microtubules in the neuron. J Cell Biol. 1999 Apr 19;145(2):305-15. 4) McNally,F.J. and Thomas,S., et al. Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs. Mol Biol Cell. 1998 Jul;9(7):1847-61. 5) Hartman,J.J., Mahr,J., McNally,K., Okawa,K., Iwamatsu,A., Thomas,S., Cheesman,S., Heuser,J., Vale,R.D. and cNally,F.J. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell. 1998 Apr 17;93(2):277-87. |
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