| CatalogCode: | NB110-41440 |
| ProductName: | Olig2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Olig2 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to a region with residues 100-200 of the human protein [NBCI# EAX09851]. There are several forms of this protein reported in the databases ~27 kDa [AAH34681], 33 kDa [AAH36245.1], and 44 kDa [EAX09851]. This immunogen has 100% identity with all three forms. |
| CrossReactivity: | This antibody reacts with human and mouse protein. Other species have not been tested. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | In Jurkat lysate, this antibody detects the 44 kDa form of this protein. Though the protein was detected, it was dirty in both mouse and human brain lysate. |
| Localization: | Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. |
| Control: | Jurkat whole cell lysate |
| Background: | The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Studies of central nervous system tumorigenesis suggests that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1 and 2) encode basic helix-loop-helix transcription factors. Human Olig genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Therefore, there is diagnostic potential of Olig markers to augment identification of oligodendroglial tumors. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-glycine, 150mM NaCl |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Oligodendrocyte transcription factor 2 antibody; anti-Oligo2 antibody; anti-Basic helix-loop-helix protein class B 1 antibody; anti-Protein kinase C-binding protein RACK17 antibody; anti-Protein kinase C-binding protein 2 antibody |
| PackageSize: | 0.1 ml |
| Homology: | 100% with human and mouse. 87% with chicken and 83% with Zebrafish. |
| GeneralRef: | 1. Yokoo, H., et al., American Journal of Pathology 164(5):1717-1725 (2004) 2. Ligon, K., Journal of Neuropathology and Experimental Neurology. 63(5): 499-509(2004) |