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| Catalog Code: | NB110-40721 |
| Product Name: | BUB3 Antibody |
| Product Description: | Rabbit Polyclonal anti-BUB3 |
| Clonality: | Polyclonal |
| ListPrice: | 350 |
| Gene ID: | 9184 |
| Immunogen: | The epitope recognized by this antibody maps to a region between residues 275 and 325 of human BUB3 using the numbering given in Swiss-Prot entry O43684 (GeneID 9184). |
| Specificity: | This antibody is specific to the human BUB3 IHC protein. |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry Formalin-Fixed Paraffin-Embedded Tissue. |
| Background: | The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | immunohistochemistry 1:100-1:500, |
| Species Summary: | Hu |
| Alternate Names: | anti-BUB3 antibody, anti-BUB-3 antibody, anti-BUB3L antibody, anti-Budding uninhibited by benzimidazoles 3 antibody, anti-HGNC:1151 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |