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| Catalog Code: | NB110-40685 |
| Product Name: | USP14 Antibody |
| Product Description: | Rabbit Polyclonal anti-USP14 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 9097 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 350 and 400 of human Ubiquitin Specific Peptidase 14 using the numbering given in entry NP_005142.1 (GeneID 9097). |
| Specificity: | This antibody is specific to the human USP14 protein. |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western Blot and Immunoprecipitation. Optimal dilution to be determined by the researcher. |
| Background: | USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions. This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | immunoprecipitation 2-5 mcg/mg lysate, Western Blot 1:2,000- 10,000 |
| Species Summary: | Hu |
| Alternate Names: | anti-USP14 antibody, anti-USP-14 antibody, anti-Ubiquitn Specific Peptidase 14 antibody, anti-TGT antibody, anti-tRNA-guanine transglycosylase antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |