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| Catalog Code: | NB110-40636 |
| Product Name: | Topo II Alpha Antibody |
| Product Description: | Rabbit Polyclonal anti-Topo II Alpha |
| Clonality: | Polyclonal |
| ListPrice: | 350 |
| Gene ID: | 7153 |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 1500 and the C-terminus (residue 1531) of human Topoisomerase (DNA) II Alpha using the numbering given in entry NP_001058.2 (GeneID 7153). |
| Specificity: | This antibody is specific to the human Topo II Alpha IHC protein. |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry Formalin-Fixed Paraffin-Embedded Tissue. |
| Background: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | immunohistochemistry 1:100-1:500, |
| Species Summary: | Hu |
| Alternate Names: | anti-TOP2A antibody, anti-TopII alpha antibody, anti-Topo II alpha antibody, anti-TP2A antibody, anti-topoisomerase II alpha (170 kDa) antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |