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| Catalog Code: | NB110-40498 |
| Product Name: | COP1 Antibody |
| Product Description: | Rabbit Polyclonal anti-COP1 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 64326 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue300 and 350 of human Constitutive Photomorphogenic Protein-1/Ring Finger and WD Repeat Domain 2 using the numbering given in entry NP_071902.2 (GeneID 64326). |
| Specificity: | This antibody is specific for the COP1/RFWD2 protein. |
| Cross Reactivity: | Human and Mouse. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western Blot and Immunoprecipitation. |
| Background: | COP1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. It is directly involved in p53 ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. It ubiquitinates p53 independently of MDM2 or RCHY1. It probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, where the ubiquitin ligase activity is mediated by RBX1. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | immunoprecipitation 2 to 5 mcg/mg, Western Blot Not Recommended. Use NB 110-40496 |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-COP1 antibody, anti-COP-1 antibody, anti-Constitutive Photomorphogenic Protein-1 antibody, anti-RFWD2 antibody, anti-RFWD-2 Ring Finger and WD Repeat Domain 2 antibody, anti-RNF2 |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
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more information: | company product webpage |