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| Catalog Code: | NB110-40413 |
| Product Name: | Noggin Antibody |
| Product Description: | Rabbit Polyclonal anti-Noggin |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide comprising residues 156-170 [PVLYAWNDLGSRFWP] of the human Noggin protein |
| Specificity: | This antibody is specific to the NOG protein. |
| Cross Reactivity: | Human. Other species not yet tested. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western Blot. |
| Background: | Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot 1:1, 000-2,000 |
| Species Summary: | Hu |
| Alternate Names: | anti-Noggin antibody, anti-Mouse Homolog of antibody, anti-Noggin precursor antibody, anti-NOG antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% sodium azide |
| Homology: | Sequence is 100% conserved in rat and mouse. |
| General References: | 1. Bachiller, D., Klingensmith, J., Kemp, C., Belo, J. A., Anderson, R. M., May, S. R., McMahon, J. A., McMahon, A. P., Harland, R. M., Rossant, J. and De Robertis, E. M. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403: 658-661, 2000. 2. Valenzuela, D.M., Economides, A.N., Rojas, E., Lamb, T.M., Nunez, L., Jones, P., Ip ,N.Y., Espinosa, R. III, Brannan, C.I., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Le Beau, M.M., Harland, R.M., and Yancopoulos,G.D., Identification of mammalian noggin and its expression in the adult nervous system. (1995) J. Neurosci. 15:6077-6084. 3. Gong, Y., Krakow, D., Marcelino, J., Wilkin, D., Chitayat, D., Babul-Hirji, R., Hudgins, L., Cremers, C.W., Cremers, F.P.M., Brunner, H.G., Reinker, K., Rimoin, D.L., Cohn, D.H., Goodman, F.R., Reardon, W., Patton, M., Francomano, C.A., and Warman,M.L., Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. (1999) Nat. Genet. 21:302-304 |
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