| CatalogCode: | NB110-39057 |
| ProductName: | Prostaglandin E Synthase Antibody |
| Product Description: | Rabbit Polyclonal anti-Prostaglandin E Synthase |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | 1st cytoplasmic domain of human |
| Specificity: | This antibody is specific to the human Prostaglandin E Synthase protein. |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Control: | Testis |
| Background: | PGES-1 is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. The expression of this protein is induced by the proinflammatory cytokine IL-1B and its' activity is glutathione dependent. PGES is also expressed at high levels in P53 expressing cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 325 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Prostaglandin E Synthase antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | 1. Forsberg L, Leeb L, Thorén S, Morgenstern R, and Jakobsson P. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. FEBS Lett (471):78-82 (2000 Apr). 2. Forsberg L, Leeb L, Thorén S, Morgenstern R, and Jakobsson P. Human glutathione dependent prostaglandin E synthase: gene structure and regulation. FEBS Lett (471):78-82 (2000 Apr). 3. Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, and Persson B. Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. Protein Sci (8):689-92 (1999 Mar). 4. Polyak K, Xia Y, Zweier JL, Kinzler KW, and Vogelstein B. A model for p53-induced apoptosis. Nature (389):300-5 (1997 Sep). |
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