| CatalogCode: | | NB110-39052 |
| ProductName: | | BACE1 Antibody |
| Product Description: | | Rabbit Polyclonal anti-BACE1 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | | near N-terminus of human |
| Specificity: | | This antibody is specific to the human BACE1 protein. |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Control: | | Brain, Alzheimers |
| Background: | | Bace 1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | peptide affinity purified |
| Host_Name: | | Rabbit |
| Buffer: | | Phosphate buffered saline |
| ListPrice: | | 325 |
| AppSummary: | | IHC |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-ASP2 antibody, anti-BACE antibody, anti-HSPC104 antibody, anti-KIAA1149 antibody |
| PackageSize: | | 0.05 mg |
| GeneralRef: | | 1. Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, and Song W. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci U S A (2006 Nov). 2. Durham TB, and Shepherd TA. Progress toward the discovery and development of efficacious BACE inhibitors. Curr Opin Drug Discov Devel (9):776-91 (2006 Nov). 3. Stockley JH, Ravid R, and O'neill C. Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain. FEBS Lett (2006 Nov). 4. McGaughey GB, Colussi D, Graham SL, Lai MT, Munshi SK, Nantermet PG, Pietrak B, Rajapakse HA, Selnick HG, Stauffer SR, and Holloway MK. beta-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites. Bioorg Med Chem Lett (2006 Nov). 5. Hu B, Xiong B, Qiu BY, Li X, Yu HP, Xiao K, Wang X, Li J, and Shen JK. Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase. Acta Pharmacol Sin (27):1586-93 (2006 Dec). |
| more information: | | company product webpage |
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