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| Catalog Code: | NB110-39045 |
| Product Name: | RAR Beta Antibody |
| Product Description: | Rabbit Polyclonal anti-RAR Beta |
| Clonality: | Polyclonal |
| ListPrice: | 350 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | C-terminal region of human |
| Specificity: | This antibody is specific to the human RAR Beta/NR1B2 protein. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Localization: | Cytoplasmic (isoform beta 4) and Nuclear (isoforms beta 1 and beta 2). |
| Background: | Retinoic acid receptor beta (RAR beta), a NR1 Thyroid Hormone-Like Receptor, is involved in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. RAR beta forms heterodimers with the retinoic acid X receptor (RXR) and binds to the direct repeat 1 (DR1) sequence of target DNA. A growing body of evidence supports the hypothesis that RAR beta is a tumor-suppressor gene. Altered expression of RAR beta has been linked to cancers, including those of the head and neck, lung, esophagus, breast, pancreas, and cervix. Three isoforms of RAR beta, beta 1, beta 2, and beta 4, have been documented in humans. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| Application Summary: | immunohistochemistry 10 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-Retinoic Acid Receptor Beta antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Hsieh JT. Evidence for the early onset of aberrant promoter methylation in urothelial carcinoma Dhawan D, Hamdy FC, Rehman I, Patterson J, Cross SS, Feeley KM, Stephenson Y, Meuth M, Catto JW, Academic Urology Unit, University of Sheffield, and Department of Urology, Royal Hallamshire Hospital, UK. Urol Oncol (24):564 (2006 Nov). 2. Koh CS, Ku JL, Park SY, Kim KH, Choi JS, Kim IJ, Park JH, Oh SK, Chung JK, Lee JH, Kim WH, Kim CW, Cho BY, and Park JG. Establishment and characterization of cell lines from three human thyroid carcinomas: Responses to all-trans-retinoic acid and mutations in the BRAF gene. Mol Cell Endocrinol (2006 Nov). 3. Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, and Gronemeyer H. International Union of Pharmacology. LX. Retinoic Acid Receptors. Pharmacol Rev (58):712-25 (2006 Dec). 4. Vernet N, Dennefeld C, Guillou F, Chambon P, Ghyselinck NB, and Mark M. Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. EMBO J (2006 Nov). 5. Bryzgunova OE, Skvortsova TE, Kolesnikova EV, Starikov AV, Rykova EY, Vlassov VV, and Laktionov PP. Isolation and comparative study of cell-free nucleic acids from human urine. Ann N Y Acad Sci (1075):334-40 (2006 Sep). |
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