| CatalogCode: | NB110-39044 |
| ProductName: | ERK Antibody |
| Product Description: | Rabbit Polyclonal anti-ERK |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | internal domain of human |
| Specificity: | This antibody is specific to the human ERK/MAPK3 protein. |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Control: | Neurons and Glia |
| Background: | ERK1, a MAPK-type protein kinase, is a member of the Ras-MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins, and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK1 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK1 causing dissociation of the MEK/ERK complex. A portion of the activated ERK1 pool forms dimers and translocates to the nucleus to activate nuclear proteins such as ELK-1 and MSK1. Cytosolic ERK 1 acts on a different set of substrates, including MNK1/2 and MAPKAP-K1. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| ListPrice: | 325 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Extracellular Signal-Regulated Kinase 1antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | 1. Moranta D, Esteban S, and GarcÃa-Sevilla JA. Acute, chronic and withdrawal effects of the cannabinoid receptor agonist WIN55212-2 on the sequential activation of MAPK/Raf-MEK-ERK signaling in the rat cerebral frontal cortex: Short-term regulation by intrinsic and extrinsic pathways. J Neurosci Res (2006 Nov). 2. Kilpatrick LE, Sun S, Mackie D, Baik F, Li H, and Korchak HM. Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of {delta}-PKC and ERK1/2. J Leukoc Biol (80):1512-1521 (2006 Dec). 3. Jover-Mengual T, Zukin RS, and Etgen AM. MAPK SIGNALING IS CRITICAL TO ESTRADIOL PROTECTION OF CA1 NEURONS IN GLOBAL ISCHEMIA. Endocrinology (2006 Nov). 4. Mitra AK, Singh RK, and Krishna M. MAP kinases: Differential activation following in vivo and ex vivo irradiation. Mol Cell Biochem (2006 Nov). 5. Cetin A, Ozturk OH, Tokay A, Akçit F, CaÄŸlar S, and YeÅŸilkaya A. Angiotensin II-Induced MAPK Phosphorylation Mediated by Ras and/or Phospholipase C-Dependent Phosphorylations but Not by Protein Kinase C Phosphorylation in Cultured Rat Vascular Smooth Muscle Cells. Pharmacology (79):27-33 (2006 Nov). |
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