| CatalogCode: | NB110-39035 |
| ProductName: | AHR Antibody |
| Product Description: | Rabbit Polyclonal anti-AHR |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | C-terminal region of human. |
| Specificity: | This antibody is specific to the human AHR protein. |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Control: | Respiratory Epithelium and Bronchial Smooth Muscle |
| Background: | Aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| ListPrice: | 325 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Ah Receptor antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | 1. Korkalainen M, Tuomisto J, and Pohjanvirta R. The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor. Biochem Biophys Res Commun (285):1121-9 (2001 Aug). 2. Korkalainen M, Tuomisto J, and Pohjanvirta R. Restructured transactivation domain in hamster AH receptor. Biochem Biophys Res Commun (273):272-81 (2000 Jun). 3. Hahn ME. The aryl hydrocarbon receptor: a comparative perspective. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol (121):23-53 (1998 Nov). 4. Pohjanvirta R, Wong JM, Li W, Harper PA, Tuomisto J, and Okey AB. Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol Pharmacol (54):86-93 (1998 Jul). 5. Hahn ME, Karchner SI, Shapiro MA, and Perera SA. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci U S A (94):13743-8 (1997 Dec). |
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