| CatalogCode: | NB110-39013 |
| ProductName: | PTPRM Antibody |
| Product Description: | Rabbit Polyclonal anti-PTPRM |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | Internal domain of human. |
| Specificity: | This antibody is specific for the human PTPRM protein. |
| CrossReactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Control: | Retina |
| Background: | PTP mu, a R2A receptor protein tyrosine phosphatase, is composed of an extracellular segment containing a MAM domain, an immunoglobulin domain and four fibronectin type III repeats, a transmembrane segment, and two intracellular protein phosphatase domains. PTP mu has been shown to affect cell-cell aggregation, regulate cardiac myocyte Kv1.5 channel expression, and promote neurite outgrowth of retinal ganglion cells. The human PTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in human cancer. PTP mu may be important in responses to pathological conditions associated with the loss of cell-cell interactions in the heart. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| ListPrice: | 325 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-PTPRL1 antibody, anti-R-PTP-MU antibody, anti-RPTPM antibody, anti-RPTPU antibody, anti-hR-PTPu antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | 1. Besco JA, Hooft van Huijsduijnen R, Frostholm A, and Rotter A. Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res (1116):50-7 (2006 Oct) 2. Fujimura Y, Iwashita M, Matsuzaki F, and Yamamoto T. MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains. Brain Res (2006 Jun) 3. Eswaran J, Debreczeni JE, Longman E, Barr AJ, and Knapp S. The crystal structure of human receptor protein tyrosine phosphatase {kappa} phosphatase domain 1. Protein Sci (2006 May) 4. Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, and Ullrich A. Furin-, ADAM 10-, and {gamma}-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of {beta}-Catenin's Transcriptional Activity. Mol Cell Biol (26):3917-34 (2006 May) 5. Xie Y, Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, and Longo FM. Protein-tyrosine Phosphatase (PTP) Wedge Domain Peptides: A NOVEL APPROACH FOR INHIBITION OF PTP FUNCTION AND AUGMENTATION OF PROTEIN-TYROSINE KINASE FUNCTION. J Biol Chem(281):16482-92 (2006 Jun) |
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