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| Catalog Code: | NB110-39011 |
| Product Name: | DDR1 Antibody |
| Product Description: | Rabbit Polyclonal anti-DDR1 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Epitope: | Human |
| Specificity: | This antibody is specific for the human DDR1 protein. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Localization: | C-terminal region of human |
| Background: | DDR1 is a DDR/TKT type protein kinase. DDR1 is activated by various types of collagen, including types I through IV. Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation. DDR1 may function in cell-to-cell interaction or recognition. At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919 amino acids, have been reported. DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| Application Summary: | immunohistochemistry 24 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-CAK antibody, anti-CD167 antibody, anti-DDR antibody, anti-EDDR1 antibody, anti-MCK10 antibody, anti-NEP antibody, anti-NTRK4 antibody, anti-PTK3 antibody, anti-PTK3A antibody, anti-RTK6 antibody, anti-TRKE antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Hou G, Vogel WF, and Bendeck MP. Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression. Circ Res (90):1147-9 (2002 Jun) 2. Hämmerle B, Vera-Samper E, Speicher S, Arencibia R, MartÃnez S, and Tejedor FJ. Mnb/Dyrk1A Is Transiently Expressed and Asymmetrically Segregated in Neural Progenitor Cells at the Transition to Neurogenic Divisions. Dev Biol (246):259-73 (2002 Jun) 3. Vogel WF. Ligand-induced shedding of discoidin domain receptor 1. FEBS Lett (514):175-80 (2002 Mar) 4. Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, and McCaughan GW. Insights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis : Analysis of Intrahepatic Differential Gene Expression. Am J Pathol (160):641-654 (2002 Feb) 5. L'hote CG, Thomas PH, and Ganesan TS. Functional analysis of discoidin domain receptor 1: effect of adhesion on DDR1 phosphorylation. FASEB J (2001 Dec) |
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more information: | company product webpage |