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| Catalog Code: | NB110-38906 |
| Product Name: | Tr3 Antibody |
| Product Description: | Rabbit Polyclonal anti-Tr3 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide (exact sequence is proprietary information). |
| Specificity: | This antibody is specific for the human Tr3/NR4A1 protein. |
| Cross Reactivity: | Human. Other species not tested. |
| Packaging: | 0.05 mg peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry. Optimal dilution to be determined by the researcher. |
| Background: | Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | Phosphate buffered saline, PH 7.7 |
| Application Summary: | immunohistochemistry 21 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-Nuclear Receptor Nak1 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.01% sodium azide |
| General References: | 1. LAvesque D, and Rouillard C. Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation. Trends Neurosci.(2006 Nov) 2. Hashida R, Ohkura N, Saito H, and Tsujimoto G. The NR4A nuclear receptor family in eosinophils. J Hum Genet (2006 Nov) 3. Cunningham NR, Artim SC, Fornadel CM, Sellars MC, Edmonson SG, Scott G, Albino F, Mathur A, and Punt JA. Immature CD4+CD8+ Thymocytes and Mature T Cells Regulate Nur77 Distinctly in Response to TCR Stimulation. J Immunol. (177):6660-6 (2006 Nov) 4. Wingate AD, and Arthur JS. Post-translational control of Nur77. Biochem Soc Trans. (34):1107-9 (2006 Dec) |
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