| CatalogCode: | NB110-38897 |
| ProductName: | XRCC1 Antibody |
| Product Description: | Rabbit Polyclonal anti-XRCC1 |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized by NB 110-38897 maps to a region surrounding residue Ser 416 of human X-ray Repair Complementing protein 1 using the numbering given in SwissProt entry P18887 (GeneID 7515). |
| Specificity: | This antibody is specific to the Phospho XRCC1 (S461) protein. |
| CrossReactivity: | Human and Mouse. Other species have not yet been tested. |
| Packaging: | 0.1 ml peptide affinity purified Rabbit antisera. |
| Uses: | This antibody can be used for imunohistochemistry. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated. |
| Control: | Human breast adenocarcinoma and mouse squamous cell carcinoma |
| Background: | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| ListPrice: | 350 |
| AppSummary: | IHC-Fr, IHC-P |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-XRCC1 antibody, anti-X-ray Repair Complementing protein 1 antibody |
| PackageSize: | 0.1 ml |
| Gene_Id: | 7515 |
| Omim_ID: | NB110-38898 |
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