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| Catalog Code: | NB110-3638 |
| Product Name: | PLAP Antibody |
| Product Description: | Mouse Monoclonal anti-PLAP (8B6) |
| Clone: | 8B6 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.7 mg/ml |
| Immunogen: | HEp-2 cells with boosted surface expression of PLAP |
| Specificity: | Human placental alkaline phosphatase, Regan and Nagao isoenzymes. No cross reaction with other isoenzymes of AP. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | Suggested working dilution for histology: 1/250-1/500. |
| Localization: | Attached to the membrane by a GPI-anchor. |
| Background: | Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG2a kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline |
| Application Summary: | ELISA, immunofluorescence, immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Radioimmunodiffusion, |
| Species Summary: | Hu, |
| Alternate Names: | anti-Alkaline phosphatase placental antibody, anti-Alkaline phosphatase placental type antibody, anti-ALP antibody, anti-ALPP antibody, anti-Glycerophosphatase antibody, anti-PLAP 1 antibody, anti-PLAP antibody, anti-PLAP1 antibody, anti-Regan isozyme antibody |
| Package Size: | 0.1 mg |
| General References: | This product has been used in:Durbin H et al. Monoclonal antibodies to placental alkaline phosphatase: preclinical evaluation in a human xenograft tumour model of F(ab')2 and Fab fragments. Int J Cancer Suppl 2:59-66 (1988). Durbin H et al. Production of monoclonal antibodies to placental alkaline phosphatase: preliminary characterisation includes identification of one antibody reactive with routinely fixed histological preparations. Int J Cancer Suppl 2:50-8 (1988). |
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