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| Catalog Code: | NB110-2557 |
| Product Name: | Proinsulin Antibody |
| Product Description: | Mouse Monoclonal anti-Proinsulin (1D3) |
| Clone: | 1D3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Full length native protein (purified) (Human). |
| Specificity: | Kd for this antibody is >3 x 10-8MDoes not cross-react with human, bovine or porcine insulin, nor does it recognise human C-peptide. |
| Cross Reactivity: | Cross-reacts with Human. Does not cross-react with Cow or Pig. Not yet tested in other species. |
| Packaging: | 0.1 mg Mouse ascites. |
| Uses: | This antibody is used for direct capture of prohormone from serum sample with insulin-specific ab8302 (7F8) as a conjugate.This antibody and ab8299 (1D6) can be also used for construction of a sensitive two-site sandwich enzyme-linked/RIA immunosorbent assays for the measurement of intact human proinsulin in serum or plasma with the detection limit in buffer 0.4 - 0.5 pmol/L.Specific immunosorbtional (immobilized 1D3) removal of proinsulin molecules from serum samples before the measurement of insulinic C-peptide. |
| Background: | A precursor of insulin, with a molecular weight of 8,000 to 10,000. It has minimum hormonal activity and is converted to insulin by removal of the connecting C peptide, leaving the two (A and B) chains. From every molecule of proinsulin, one molecule of insulin plus one molecule of C Peptide are produced. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | PBS with pH 7.4 |
| Application Summary: | ELISA , RID |
| Species Summary: | Hu, Bv(-), Po(-) |
| Alternate Names: | anti-INS antibody, anti-insulin antibody, anti-Insulin precursor antibody, anti-Proinsulin antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.1% sodium azide |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: 1D3 - 7F8, D6C4 or D3E7 For Sandwich ELISA pair this antibody with: NB600-1448, NB120-8304, NB200-435 |
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