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| Catalog Code: | NB110-2308 |
| Product Name: | Cyclin D1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cyclin D1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide (Human) (C terminal). |
| Specificity: | Reacts with cyclin D1 and weakly cross reactive with cyclin D2 |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 1 ml IgG purified Rabbit antisera. |
| Background: | During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS and 0.2% gelatin |
| Application Summary: | immunohistochemistry-Fr, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-B cell ccl/lymphoma 1 antibody, anti-B cell leukemia 1 antibody, anti-BCL1 antibody, anti-BCL1 oncogene antibody, anti-CCND 1 antibody, anti-CCND1 antibody, anti-CCND1 protein antibody, anti-CCND1/IGHG1 fusion gene antibody, anti-D11S287E antibody, anti-G1/S specific cyclin D1 antibody, anti-Parathyroid adenomatosis 1 antibody, anti-PRAD1 antibody, anti-PRAD1 oncogene antibody, anti-U21B31 antibody |
| Package Size: | 1 ml |
| Preservative: | 0.1% sodium azide |
| General References: | General / background references:Geng Y et al. Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97:767-77 (1999). Prall OW et al. Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J Biol Chem 272:10882-94 (1997). Musgrove EA et al. Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation. J Cell Biochem 60:363-78 (1996). Sauer K & Lehner CF The role of cyclin E in the regulation of entry into S phase. Prog Cell Cycle Res 1:125-39 (1995). Desdouets C et al. Cyclin A: function and expression during cell proliferation. Prog Cell Cycle Res 1:115-23 (1995). Bandara LR et al. Cyclin A recruits p33cdk2 to the cellular transcription factor DRTF1. J Cell Sci Suppl 16:77-85 (1992). |
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