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| Catalog Code: | NB110-1948 |
| Product Name: | Cyclooxygenase 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cyclooxygenase 2 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Immunogen: | Recombinant full length protein (Human). |
| Epitope: | carboxy-terminus of human Cox-2. |
| Specificity: | The antibody does not cross react with Cox-1. |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 0.1 ml Whole Rabbit antisera. |
| Localization: | Membrane associated. Microsomal membrane. |
| Background: | Cox-2 (Cyclooxygenase-2) is an inducible enzyme that is normally absent from cells, however, in response to growth factors, tumor promoters and some cytokines, it undergoes a rapid and transient expression. The antibody recognizes Cox-2 at 70kDa in Sf9 cell lines transfected with Cox-2 as well as in WISH cells induced with IL-1b. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 0.02M K Phosphate, 0.15M NaCl, pH7.2 |
| Application Summary: | immunoprecipitation , Immunohistochemistry-Paraffin 1/100, Immunohistochemistry-Frozen /100 |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | Anti-COX 2 antibody; Anti-COX2 antibody; Anti-Cyclooxygenase 2 antibody; Anti-Cyclooxygenase antibody; Anti-Cyclooxygenase2 antibody; Anti-hCox 2 antibody; Anti-PGG/HS antibody; Anti-PGH synthase 2 antibody; Anti-PGHS 2 antibody; Anti-PGHS2 antibody; Anti-PHS 2 antibody; Aniti-PHS II antibody; Anti-PHS2 antibody; Anti-Prostaglandin endoperoxide synthase 2 antibody; Anti-Prostaglandin G/H synthase 2 precursor antibody; Anti-Prostaglandin G/H synthase and cyclooxygenase antibody; Anti-Prostaglandin G/H synthase antibody; Anti-Prostaglandin H2 synthase 2 antibody; Anti-PTGS2 antibody; Anti-TIS10 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% Sodium Azide |
| Notes Main: | COX-2, also known as prostaglandin H synthase, was identified less than a decade ago. Its discovery was followed by a period of discovery and drug development to create a ?super aspirin? and led to insights into arthritis, Alzheimer's disease, colorectal cancer and regulation of brain and kidney function in search of better treatments for degenerative and inflammatory diseases. Two different isoforms of the enzyme are known, Cox-1 and Cox-2. |
| General References: | This product has been used in:Tong M & Tai HH Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Biochem Biophys Res Commun 276:77-81 (2000). Guan Z et al. Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem 273:28670-6 (1998). |
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