| CatalogCode: | | NB110-16214 |
| ProductName: | | Galectin 3 Antibody |
| Product Description: | | Rabbit Polyclonal anti-Galectin 3 |
| Clonality: | | Polyclonal |
| Immunogen: | | Recombinant fragment: GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI, corresponding to amino acids 151-251 of Galectin 3. |
| CrossReactivity: | | Cross-reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | | 0.2 ml protein A purified Rabbit antisera. |
| Uses: | | WB: Detects a band of approximately 30 kDa (predicted molecular weight: 26 kDa). |
| Localization: | | Nuclear. Cytoplasmic in adenomas and carcinomas. |
| Background: | | Galectins are a new family of animal lectins which appear to exhibit a variety of biological functions. Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin 3 is one of the more extensively studied members of this family and is a 30 kDa protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Galectin 3 is normally distributed in epithelia of many organs, in various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | protein A purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50% Glycerol, PBS. pH 7.2 |
| ListPrice: | | 325 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu, Mu |
| ALTnames: | | anti-35 kDa lectin antibody, anti-Carbohydrate binding protein 35 antibody, anti-CBP 35 antibody, anti-GAL3 antibody, anti-Galactose specific lectin 3 antibody, anti-Galactoside binding protein antibody, anti-GALBP antibody, anti-IgE binding protein antibody, anti-L 34 antibody, anti-Laminin binding protein antibody, anti-Lectin galactose binding soluble 3 antibody, anti-Lectin galactoside binding soluble 3 antibody, anti-LGALS3 antibody, anti-MAC 2 antigen antibody, anti-MAC2 antibody |
| ProteinTarget: | | Galectin 3 |
| PackageSize: | | 0.2 ml |
| GeneralRef: | | General / background references:Iacobini C et al. Role of galectin-3 in diabetic nephropathy. J Am Soc Nephrol 14:S264-70 (2003). Takenaka Y et al. Malignant transformation of thyroid follicular cells by galectin-3. Cancer Lett 195:111-9 (2003). Huflejt ME et al. L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. J Biol Chem 268:26712-8 (1993). Lotz MM et al. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc Natl Acad Sci U S A 90:3466-70 (1993). |
| more information: | | company product webpage |
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