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| Catalog Code: | NB110-11812 |
| Product Name: | Ghrelin Antibody |
| Product Description: | Mouse Monoclonal anti-Ghrelin (Ghr2) |
| Clone: | Ghr2 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 1.2 mg/ml |
| Immunogen: | Synthetic peptide (Human). |
| Cross Reactivity: | Cross-reacts with Human. Expected to cross-react with Mouse due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 13 kDa. |
| Localization: | Secreted |
| Background: | Ghrelin was originally discovered as a preprohormone that stimulates the release of growth hormone from the anterior pituitary. Recent studies have shown that ghrelin, in concert with other hormones, helps to control both appetite and energy balance. The synthesis of ghrelin takes place predominantly in epithelial cells of the stomach, although it is also produced in smaller quantities in the placenta, kidney, pituitary and hypothalamus. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release from the pituitary. It has an appetite stimulating effect, induces adiposity, and stimulates gastric acid secretion, and it is involved in growth regulation. Ghrelin is synthesized as a preprohormone (13kDa), then proteolytically processed to yield a 28 amino acid peptide (3kDa). Obestatin, an appetite suppressing peptide hormone, is also produced in the process. An interesting and unique modification is imposed on the ghrelin hormone during synthesis in the form of octanoic acid bound to one of its amino acids. This modification is necessary for biological activity. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG3 |
| Host Name: | Mouse |
| Buffer: | 0.1M Sodium Chloride, 0.05M Phosphate. pH 7.4 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-Ghrl antibody, anti-Growth hormone secretagogue antibody, anti-Growth-hormone releasing protein antibody, anti-Motilin-related peptide antibody, anti-M46 protein antibody, anti-Mtlrp antibody, anti-MTLRPAP antibody, anti-Appetite-regulating hormone antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.1% Sodium |
| General References: | General / background references:Gaytan F et al. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J Clin Endocrinol Metab 89:400-9 |
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