| CatalogCode: | NB110-10444 |
| ProductName: | IL2 Antibody |
| Product Description: | Rat Monoclonal anti-IL2 (JES6-5H4), conjugated to FITC |
| Clone: | JES6-5H4 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant full length protein (Mouse). |
| Specificity: | NB110-10444 recognises natural and recombinant mouse IL2. This antibody may be used to detect intracellular IL2 in flow cytometric applications. |
| CrossReactivity: | Cross-reacts with Mouse. |
| Packaging: | 0.1 mg Immunogen affinity purified Rat ascites. |
| Uses: | FACS: Use at a dilution of neat. Membrane permeabilisation is required for this application. |
| Localization: | Secreted |
| Background: | Human interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b |
| Host_Name: | Rat |
| Buffer: | Constituents: 0.5% BSA, PBS |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | anti-Aldesleukin antibody, anti-Interleukin 2 antibody, anti-Lymphokine antibody, anti-T Cell Growth Factor antibody, anti-TCGF antibody |
| ProteinTarget: | IL2 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| NotesMain: | Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use. |