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| Catalog Code: | NB100-94887 |
| Product Type: | Primary Antibody |
| Product Name: | NRAS Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 4893 (human); 18176 (mouse); 24605 (rat) |
| Host: | Goat |
| Isotype: | IgG |
| Product Description: | Goat Polyclonal anti-NRAS |
| Cross Reactivity: | Human |
| Species Summary: | Hu(+) |
| Background: | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq] |
| Alternate Names: | anti-NRAS antibody, anti-neuroblastoma RAS viral (v-ras) oncogene homolog antibody, anti-N-ras antibody, anti-NRAS1 antibody, anti-N-ras protein part 4 antibody, anti-v-ras neuroblastoma RAS viral oncogene homolog antibody |
| Immunogen: | Peptide with sequence C-RMKKLNSSDDGTQ, from the internal region of the protein sequence according to NP_002515.1. |
| Epitope: | C-RMKKLNSSDDGTQ |
| Purity: | Immunogen affinity purified |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| Preservative: | 0.02% sodium azide |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Package Size: | 0.1 mg |
| Concentration: | 0.5 mg/ml |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx. 21kDa band observed in Human lysates of cell line A431 (calculated MW of 21.2kDa according to NP_002515.1). Recommended concentration: 0.01-0.03ug/ml. |
| Application Summary: | ELISA 1:32000, Western Blot 0.01-0.03ug/ml, |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
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