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| Catalog Code: | NB100-93468 |
| Product Type: | Primary Antibody |
| Product Name: | ABCA4 Antibody |
| List Price: | 195 |
| Clonality: | Polyclonal |
| Gene ID: | 24 |
| Host: | Goat |
| Isotype: | IgG |
| Product Description: | Goat Polyclonal anti-ABCA4 |
| Cross Reactivity: | Human, Dog |
| Species Summary: | Hu, Ca |
| Background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq] |
| Alternate Names: | anti-ABCA4 antibody, anti-ATP-binding cassette, sub-family A (ABC1), member 4 antibody, anti-ABC10 antibody, anti-ABCR antibody, anti-ARMD2 antibody, anti-CORD3 antibody, anti-DKFZp781N1972 antibody, anti-FFM antibody, anti-RMP antibody, anti-RP19 antibody, anti-STGD antibody, anti-STGD1 antibody, anti-ATP binding cassette transporter antibody, anti-ATP-binding cassette, sub-family A member 4 antibody, anti-ATP-binding transporter, retina-specific antibody, anti-retina-specific ABC transporter antibody, anti-rim protein antibody |
| Immunogen: | Peptide with sequence C-KQQTESHDLPLHPR, from the C Terminus of the protein sequence according to NP_000341.2. |
| Epitope: | C-KQQTESHDLPLHPR |
| Purity: | Immunogen affinity purified |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| Preservative: | 0.02% sodium azide |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Package Size: | 0.1 mg |
| Concentration: | 0.5 mg/ml |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:8,000. Western Blot: Preliminary experiments in Human Liver lysates and in Mouse Eye and Rat Retina lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? |
| Application Summary: | ELISA 1:8000, Western Blot 1ug/ml, |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| General References: | Singh HP, Jalali S, Hejtmancik JF, et al. Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy Am J Ophthalmol. 2006 May;141(5):906-13 PMID: 16546111 |
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