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| Catalog Code: | NB100-93421 |
| Product Type: | Primary Antibody |
| Product Name: | NPEPPS Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 9520 |
| Host: | Goat |
| Isotype: | IgG |
| Product Description: | Goat Polyclonal anti-NPEPPS |
| Cross Reactivity: | Human |
| Species Summary: | Hu(+) |
| Background: | This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq] |
| Alternate Names: | anti-NPEPPS antibody, anti-aminopeptidase puromycin sensitive antibody, anti-MP100 antibody, anti-PSA antibody, anti-metalloproteinase MP100 antibody, anti-puromycin-sensitive aminopeptidase antibody |
| Immunogen: | Peptide with sequence C-KRDAESIHQYLLQRK, from the internal region of the protein sequence according to NP_006301.2. |
| Epitope: | C-KRDAESIHQYLLQRK |
| Purity: | Immunogen affinity purified |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| Preservative: | 0.02% sodium azide |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Package Size: | 0.1 mg |
| Concentration: | 0.5 mg/ml |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:4,000. Western Blot: Approx 110kDa band observed in Human Brain (Cerebral Cortex) lysates (calculated MW of 98.5kDa according to NP_006301.2). Recommended concentration: 0.2-0.5ug/ml. |
| Application Summary: | ELISA 1:4000, Western Blot 0.2-0.5ug/ml, |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| General References: | Karsten SL, Sang TK, Gehman LT, et al. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron. 2006 Sep 7;51(5):549-60. PMID: 16950154 |
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