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| Catalog Code: | NB100-93398 |
| Product Type: | Primary Antibody |
| Product Name: | FZD7 Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 8324 |
| Host: | Goat |
| Isotype: | IgG |
| Product Description: | Goat Polyclonal anti-FZD7 |
| Cross Reactivity: | Human |
| Species Summary: | Hu(+) |
| Background: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq] |
| Alternate Names: | anti-FZD7 antibody, anti-frizzled homolog 7 (Drosophila) antibody, anti-FzE3 antibody, anti-Frizzled, drosophila, homolog of, 7 antibody, anti-frizzled 7 antibody |
| Immunogen: | Peptide with sequence C-RFYHRLSHSSKGET, from the C Terminus of the protein sequence according to NP_003498.1. |
| Epitope: | C-RFYHRLSHSSKGET |
| Purity: | Immunogen affinity purified |
| Buffer: | Tris-saline [pH7.3] with 0.5% BSA |
| Preservative: | 0.02% sodium azide |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Package Size: | 0.1 mg |
| Concentration: | 0.5 mg/ml |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:64,000. Western Blot: Approx 60kDa band observed in lysates of cell lines HEK293 and HepG2 (calculated MW of 63.6kDa according to NP_003498.1). Recommended concentration: 0.3-1ug/ml. |
| Application Summary: | ELISA 1:64000, Western Blot 0.3-1ug/ml, |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| General References: | Vincan E, Darcy PK, Farrelly CA, et al. Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. Oncogene. 2007 Apr 5;26(16):2340-52. Epub 2006 Oct 2. PMID: 17016432 |
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