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| Catalog Code: | NB100-93326 |
| Product Type: | Primary Antibody |
| Product Name: | NUP96 Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 4928 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-NUP96 |
| Cross Reactivity: | Human |
| Species Summary: | Hu(+) |
| Background: | Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq] |
| Alternate Names: | anti-UP96 antibody, anti-NUP-96 antibody, anti-Nucleoporin 96kDa. antibody |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 1650 and 1700 of human nucleoporin 96kDa using the numbering given in entry NP_057404.2 (GeneID 4928). |
| Purity: | Immunogen affinity purified |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Preservative: | 0.09% Sodium Azide |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 1 mg/ml |
| Uses: | This antibody is useful for immunoprecipitation. It is not recommended for western analysis. |
| Application Summary: | immunoprecipitation 2-5 mcg/mg lysate |
| Storage: | Store at 4C. Do not freeze. |
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