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| Catalog Code: | NB100-93319 |
| Product Type: | Primary Antibody |
| Product Name: | NIPBL Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 25836 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-NIPBL |
| Cross Reactivity: | Human |
| Species Summary: | Hu(+) |
| Background: | This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Alternate Names: | anti-IPBL antibody, anti-Nipped-B-Like antibody, anti-IDN3 antibody, anti-SCC2 antibody, anti-Delangin. antibody |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 550 and 600 of human Nipped-B-like using the numbering given in entry NP_597677.2 (GeneID 25836). |
| Purity: | Immunogen affinity purified |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Preservative: | 0.09% Sodium Azide |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 1 mg/ml |
| Uses: | This antibody is useful for immunoprecipitation. It is not recommended for western analysis. |
| Application Summary: | immunoprecipitation 2-5 mcg/mg lysate |
| Storage: | Store at 4C. Do not freeze. |
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