| CatalogCode: | | NB100-890 |
| ProductName: | | PINX1 Antibody |
| Product Description: | | Goat Polyclonal anti-PINX1 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide SMLAERRRKQKWAV, representing the N-Terminus of the human protein (residues 2-15) according to NP_060354 |
| CrossReactivity: | | Cross-reacts with Human. Expected to cross-react with Mouse due to sequence homology. Not yet tested in other species. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | This antibody can be used for Western Blot, approx 35kDa bands seen in HeLa lysate. Not tested in other applications. Recommended Starting Dilution:*WB: at 1-3ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | | PINX1 is a protein that contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-67-11-3 protein antibody, anti-Hepatocellular carcinoma-related putative tumor suppressor antibody, anti-LPTL antibody, anti-LPTS antibody, anti-PIN2 interacting protein 1 antibody, anti-FLJ20565 antibody, anti-MGC8850 antibody |
| ProteinTarget: | | PINX 1 |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | Zhou XZ & Lu KP The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347-59 (2001). |
| NotesMain: | | Principal Names ? PINX1; PIN2-interacting protein 1; LPTL; LPTS; MGC8850; FLJ20565; 67-11-3 protein; hepatocellular carcinoma-related putative tumor suppressor.Official Gene Symbol - PINX1 (interim symbol).GenBank Accession Number ? NP_060354.LocusLink ID - 54984; 72400 (mouse).Please note: We have been contacted by a researcher working with PINX1 to advise that recent research has shown that there are two splice variants of PINX1, one at 45 kDa (full lenth) and the other at 20 kDa (C-terminus truncated). This antibody detects a band at 37kDa in Jurkat Lysate. The researcher is currently testing this antibody to confirm that the band we find at 37 kDa is infact PINX1. We would be interested to hear back from any other researchers working with PINX1. 11 March, 2004. |
| Gene_Id: | | 54984 |
| Omim_ID: | | H00054984-A01 |
| more information: | | company product webpage |