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| Catalog Code: | NB100-877 |
| Product Name: | PTP4A3 Antibody |
| Product Description: | Goat Polyclonal anti-PTP4A3 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 11156 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide with sequence NRPAPVEVSYKHMR, representing the N Terminus from the second Met of the protein (residues 5-18 according to NP_009010; NP_116000. |
| Cross Reactivity: | Cross-reacts with Human. Expected to cross-react with Mouse due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used in Western Blot where a 22kDa band is seen in Human Pancreas lysate. The observed band size is in agreement with Matter WF et al. (Biochem Biophys Res Commun 2001 May 25;283(5):1061-8).Recommended Starting Dilutions*:Western Blot: 1.0-3.0ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Potentially prenylated protein tyrosine phosphatase antibody, anti-PRL3 antibody, anti-PRLR antibody, anti-Protein tyrosine phosphatase 4a3 antibody, anti-Protein tyrosine phosphatase of regenerating liver 3 antibody, anti-Protein tyrosine phosphatase type IVA member 3 antibody, anti-Protein tyrosine phosphatase type IVA protein 3 antibody, anti-PRL-3 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Saha S et al. A phosphatase associated with metastasis of colorectal cancer. Science 294:1343-6 (2001). |
| Novus References: | Fagerli, U., et al. Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. Blood, Oct 2007; doi:10.1182/blood-2007-07-101139. 2. Fagerli,U., et al. Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. Blood, Jan 2008; 111: 806 - 815. |
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