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| Catalog Code: | NB100-874 |
| Product Name: | NUMB Antibody |
| Product Description: | Goat Polyclonal anti-NUMB |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Gene ID: | 8650 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide with sequence PFSSDLQKTFEIEL, representing the C Terminus of the human protein (residues 638-651) according to NP_003735. |
| Cross Reactivity: | Tested: Mouse Expected from sequence similarity: Human, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:16,000. Western Blot: Approx 80kDa band observed in Mouse Brain lysates (calculated MW of 70.9kDa according to NP_001005743.1). Recommended concentration: 0.3-1.0 µg/ml. |
| Background: | The NUMB and Numb-like genes are essential during nervous system development. Numb proteins function to maintain the self-renewal properties of all neural progenitor cells and could play similar roles in stem-cell maintenance in other tissues. Mice ablated for either NUMB or Numb-like in the nervous system are born normally, however deletion of both genes results in embryonic lethality (E11.5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| Application Summary: | ELISA , immunofluorescence 1:200, immunoprecipitation 1:1, Western Blot 0.5-1.0ug/ml, Immunohistochemistry-Frozen |
| Species Summary: | Mu, , |
| Alternate Names: | anti-NUMB antibody, anti-S171 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.02% Na azide |
| General References: | Zhong W et al. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17:43-53 (1996). PUBMED:8755477 |
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